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Laboratory studies demonstrate that FOXO4-DRI can eliminate chemotherapy-induced senescent cells that may contribute to administration resistance, while the timing of senolytic administration relative to chemotherapy requires careful optimization in experimental designs

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Although it has been argued that clinically relevant doses of APAP should be used in such studies, it is expected that recapitulating conditions in susceptible humans using healthy laboratory animals will require higher drug doses than those commonly encountered by humans (Fig

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